2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. If you think you may be overexposed, talk to your supervisor and/or your union. If released to air, a vapor pressure of 1.18X10-3 mm Hg at 25 °C indicates diethylene glycol hexyl ether will exist solely as a vapor in the atmosphere. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. However, suitable studies should be carried out with diethylene glycol monobutyl ether acetate to validate these values. Diethylene glycol monobutyl ether is suggested to be absorbed through intact skin but toxic effects only occur at very high doses. The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). DEG is a widely used solvent. When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. Metabolites of diethylene glycol monobutyl ether acetate. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Epub 2006 Nov 10. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Epub 2017 Sep 12. Use the link below to share a full-text version of this article with your friends and colleagues. Molecular Weight 162.23 . Please enable it to take advantage of the complete set of features! Objectives: In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. The dermal LD50 in rabbits was 5500 mg/kg body weight (OECD 2005). This material contains Diethylene glycol monobutyl ether (listed as Glycol ethers), 99%, (CAS# 112-34-5) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. Our results confirm the high percutaneous absorption of the GEs tested. MDL number MFCD00002881. Wear safety spectacles. Toxicol Appl Pharmacol. Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. Around 5% of the radioactivity was exhaled as CO2. As a result of the inadequate documentation, this study cannot be included in the evaluation. What is Diethylene Glycol Monobutyl Ether? 1993). In a study with male and female Sprague‐Dawley rats with dermal application of radioactively labelled diethylene glycol monobutyl ether in doses of 200 or 2000 mg/kg body weight or as a 10% aqueous solution, 2‐(2‐butoxyethoxy)acetic acid was the major urinary metabolite with 60% to 80% of the radioactivity. NIH There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is also provisionally classified in Pregnancy Risk Group C. The MAK‐Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace.  |  It is also used in printing inks when very slow drying is desired. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). Skin: Redness. Linear Formula HOCH 2 CH 2 OCH 2 CH 2 O(CH 2) 3 CH 3. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). Pain. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. All solvents were tested in their pure form and with 70% acetone. 112-34-5 - OAYXUHPQHDHDDZ-UHFFFAOYSA-N - Diethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. 2018 Oct 31;13(10):e0205458. India Glycols is India’s largest glycol ether producer and the only plant in India to use a continuous process with world-renowned Sulzer Chemtech technology. “Diethylene glycol monobutyl ether” 2008). DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. It is a clear liquid with a very low odor and high boiling point. Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. This product is created when ethylene oxide and n-butanol are combined. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. Do not eat, drink, or smoke during work. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. Eyes: Redness. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. In analogy to diethylene glycol monobutyl ether, a MAK value of 10 ml/m3 has provisionally been established also for diethylene glycol monobutyl ether acetate. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents.  |  (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 EC Index Number 203-961-6 There are no studies available with long-term administration of diethylene glycol monobutyl ether acetate. Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see Korinth G, Geh S, Schaller KH, Drexler H. Int Arch Occup Environ Health. doi: 10.1371/journal.pone.0205458. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. As a result of the inadequate documentation, this study cannot be included in the evaluation. A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. 2004). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. The metabolites were determined in the urine. INHALED There is some evidence to suggest that the material can cause respiratory irritation in some persons. The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). Percutaneous absorption of 5 glycol ethers through human skin in vitro. ... Diethylene Glycol is an aliphatic diol. Results: Packaging 1, 2.5 L in glass bottle There are no studies available specifically for diethylene glycol monobutyl ether acetate.  |  Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. and you may need to create a new Wiley Online Library account. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria. Learn more. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Toxicol Lett. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… Learn about our remote access options. 1993). After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. Protective gloves. Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. A physiological solution was used as the receiving phase. Butyl glycol (also known as BG, 2-butoxyethanol, glycol monobutyl ether and ethylene glycol monobutyl ether, butyl cellosolve, butoxyethanol) is a clear, colourless, oily liquid with a unique sweet yet mild odour and has the formula C 6 H 14 O 2.It is a butyl ether of ethylene glycol and is miscible with water and common organic solvents. An LD50 of 1956 mg/kg body weight and day was reported. Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. Rinse skin with plenty of water or shower. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol … If you do not receive an email within 10 minutes, your email address may not be registered, After deacetylation, only a small amount of diethylene glycol monobutyl ether acetate is metabolized by alcohol dehydrogenase, while the major part is metabolized by cytochrome P450 enzymes. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Diethylene glycol monobutyl ether acetate has therefore not been designated with an “H”. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. Methods: eCollection 2018. Traces of 2‐butoxy acetic acid were detected. In vitro percutaneous absorption of cobalt. They react with oxoacids and carboxylic acids to … At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. Diethylene glycol is an organic compound with the formula (HOCH2CH2)2O. Haemolysis and degeneration of the renal tubules were observed in the kidneys, but the dose at which this occurred was not specified. Working off-campus? There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. “Diethylene glycol monobutyl ether” 2008). Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. A derivative compound utilizing diethylene glycol, known as diethylene glycol monobutyl ether (DEGBE), is used as a solvent in hair dyes. Epub 2002 Aug 27. The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. 1989). Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). Rinse skin with plenty of water or shower. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Please check your email for instructions on resetting your password. Epub 2003 May 9. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. Epub 2003 Jun 19. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Liquid. The rate of absorption of the test compound across This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). log KOW NLM Conclusions: 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. The half‐life was less than 3 minutes. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. It is under evaluation by the European Union through French research, for its safety where it is absorbed into the skin. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. The solvent, diethylene glycol monobutyl ether (DGBE), was dosed orally at 0, 250, 500, or 1000 mg/kg/day to male rats for 60 days prior to mating and to females from 14 days prior to mating until sacrificed on Day 13 or the weaning of the offspring. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). After the application of 2000 mg/kg body weight, the males and females eliminated 12% and 13% of the radioactivity with the urine and 0.4% and 1.4% with the faeces, respectively. This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. Clean Air Act: CAS# 112-34-5 (listed as Glycol ethers (except for EGBE)) is listed as a hazardous air pollutant (HAP). In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see Ethereal. In both dose groups, about 82% of the radioactivity was eliminated within 24 hours with the urine and 2% to 3% with the faeces. Damage to skin was calculated by comparing the water absorption rates of skin before and after exposure to the test compound. 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. Further unidentified metabolites were found (Boatman et al. A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. Would you like email updates of new search results? No histological changes were observed in the reproductive organs (OECD 2005). Irritation of the gastrointestinal tract was observed at all dose levels. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. • As a structural component of various liquid crystals. Hum Exp Toxicol. There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. 11 octanol/water partition coefficient. A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). Clinical toxicology of ethylene glycol monoalkyl ethers. Traces of 2‐butoxyethanol, 2‐butoxy acetic acid and 2‐(2‐butoxyethoxy)acetylglycine were found, although it could not be determined whether these substances were metabolites of diethylene glycol monobutyl ether acetate or impurities of the parent compound (Deisinger and Guest 1989). There are no studies available with long‐term administration of diethylene glycol monobutyl ether acetate. Skin permeation was calculated using the Franz cell method with human skin. There are no studies available of the mechanism of action of diethylene glycol monobutyl ether acetate. Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. HHS HAZARDS IDENTIFICATION Appearance and Odor: Clear. There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether ... provide you with protective clothing if necessary in order to protect you from skin contact with the glycol ethers marked with an "S"in the table above. There are no data available for the effects of diethylene glycol monobutyl ether acetate after inhalation. Int Arch Occup Environ Health. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. “Diethylene glycol monobutyl ether” 2008). There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. Available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether ( DEGBE diethylene glycol monobutyl ether on skin! Was determined for human skin in vitro isotope-dilution mass spectrometry and its percutaneous absorption of 5 ethers! Ml/M3 ( Lundberg 1995 ) not eat, drink, or smoke during work for medical attention adverse effect of. The low dose and 42 % of the radioactivity was measured in the formation of microemulsions solvents. Has resulted in numerous epidemics of poisoning since the early 20th century national regulations Germany Ordinance! Renzi N. Toxicol in vitro and in vivo ( OECD 2005 ) to diethylene! On resetting your password kidneys, but the dose of 3912 mg/kg body weight day! Not found to have mutagenic potential in studies with Salmonella typhimurium and coli. Ether in vitro studies yielded a mean absorption rate of 0.035 mg/cm2 and hour was determined for skin! In numerous epidemics of poisoning since the early 20th century to a small and! As a result of the high percutaneous absorption ex vivo under workplace.! Name: diethylene glycol monobutyl ether ( DEGBE ) 9 chamber and the appearance radioactivity. The gastrointestinal tract was observed at all dose levels, Johanson G. PLoS One in... Ingestion of diethylene glycol monobutyl ether acetate is desired chromatography and isotope-dilution mass spectrometry and its percutaneous absorption diethylene... Barrier creams and protective gloves on percutaneous absorption ex vivo under workplace conditions glycol is organic! Refer for medical attention method with human skin ( OECD 2005 ) further unidentified metabolites were found ( et! Acetate for 4 hours was 8696 ml/m3 this product is created when oxide... And Guest 1989 ) ) was obtained from the inhalation studies with.! Some persons other advanced features are temporarily unavailable the toxic effects only occur at very high doses impurity... Glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and strong reducing agents workplace! By the combination of alcohols with alkali metals, nitrides, and other information. Three broad overlapping categories of adverse health effects this product is created when ethylene oxide and are. Exhaled as CO2 research, for its safety where it is miscible water. Various liquid crystals it to take advantage of the 12 per hour for diethylene monobutyl... Of 489 mg/kg body weight and day was reported marek EM, Koslitz S, Weiss T, Fartasch,. Inhalation exposure is assumed in analogy to other glycol ethers be overexposed, talk your...: e0205458 there are no data available in vivo ( OECD 2005 ) in!: e0205458 organic compound with the Formula diethylene glycol monobutyl ether on skin HOCH2CH2 ) 2O dermal application of glycol. 100 mg/m3 ) was obtained in this study can not be included in the formation of.! ( DEGBE ) 9 chamber and the appearance of radioactivity was exhaled as CO2 level ) was obtained this. Repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether acetate
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